Humboldt-Universität zu Berlin - SALSA School of Analytical Sciences Adlershof

Mambo Lab

The Mambo Lab (Mass Spectrometry Berlin Open Access Lab) offers modern measuring equipment that can be used by PhD students and researchers to advance their projects. Our facility is equipped with modern mass spectrometers for imaging mass spectrometry. The two existing MALDI-Orbitrap instruments allow spatially resolved molecular mass spectrometric measurements of the distribution of specific target compounds in tissues or materials. The available cryomicrotome is capable of producing extremely thin sections that can be used in the mentioned mass spectrometers or other techniques.

Contact

 

Dr. Sebastian Beck

s.beck@chemie.hu-berlin.de

Tel. +49 30 2093 82836

 

For inquiries regarding laboratory usage, please contact Dr. Sebastian Beck.

Collaborative Publications with Mambo Lab

 

  • Letourneau, D. R., Marzullo, B. P., Alexandridou, A., Barrow, M. P., O'Connor, P. B., Volmer, D. A., Characterizing lignins from various sources and treatment processes after optimized sample preparation techniques and analysis via ESI-HRMS and custom mass defect software tools. Anal Bioanal Chem., 2023, 415(27): 6663-6675.
  • Petran, C. Filip, D. Bogdan, C. Zimmerer, S. Beck, T. Radu, J. Liebscher, Oxidative polymerization of 3,4-dihydrobenzylamine – the lower homolog of dopamine, Langmuir, 2023, 39(15), 5610-5620.
  • S. van Wasen, Y. You, S. Beck, J. Riedel, D.A. Volmer, Miniaturized Protein Digestion using Acoustic Levitation with Online High Resolution Mass Spectrometry, Anal. Chem., 2023, 95(8), 4190-4195.
  • Y. Hontani, J. Mehlhorn, T. Domratcheva, S. Beck, M. Kloz, P. Hegemann, T. Mathes, J.T.M. Kennis, Spectroscopic and computational observation of glutamine tautomerization in the blue light sensing using flavin domain photoreaction, J. Am. Chem. Soc., 2023, 145(2), 1040-1052.
  • Letourneau, D. R., August, D. D., & Volmer, D. A., New algorithms demonstrate untargeted detection of chemically meaningful changing units and formula assignment for HRMS data of polymeric mixtures in the open-source constellation web application. Journal of Cheminformatics, 2023, 15(1), 7.
  • S. van Wasen, Y. You, S. Beck, J. Riedel, D.A. Volmer, Laser ablation secondary electrospray ionization for in-situ mass spectrometric interrogation of acoustically-levitated droplets, Anal. Chem., 2022, 94(49), 16992-16996.
  • Letourneau, D. R., & Volmer, D. A., Mass spectrometry‐based methods for the advanced characterization and structural analysis of lignin: A review. Mass spectrometry reviews, 2023, 42(1), 144-188.
  • S. van Wasen, Y. You, S. Beck, J. Riedel, D.A. Volmer, Quantitative analysis of pharmaceutical drugs using a combination of acoustic levitation and high resolution mass spectrometry, Anal. Chem., 2021, 93(15), 6019-6024.
  • Lores Lareo, P., Linscheid, M. W., & Seitz, O., Nucleic acid and SNP detection via template‐directed native chemical ligation and inductively coupled plasma mass spectrometry. Journal of mass spectrometry, 2019, 54(8), 676-683.
  • D. Benda, N. Lüttgert, S. Beck, Peptide quantification in elemental mass spectrometry using a photoclevable metal‐coded affinity tag (MeCAT) reagent, Rapid Comm. Mass Spectrom., 2019, 33(10), 978-980.
  • S. Trog, A.H. El-Khatib, S. Beck, M.R. Makowski, N. Jakubowski, M.W. Linscheid, Complementarity of molecular and elemental mass spectrometric imaging of GadovistTM in mice tissues, Anal. Bioanal. Chem., 2019, 411(3), 629-637.
  • D. Benda, S. Beck, M.W. Linscheid, Synthesis and characterization of a new MeCAT reagent containing a photocleavable linker for labeling of proteins and peptides in mass spectrometric analyses, Talanta, 2019, 192, 197-203.
  • E. Moreno-Gordaliza, D. Esteban-Fernández, A. Lázaro, S. Aboulmagd, B. Humanes,  A. Tejedor, M.W. Linscheid, M.M. Gómez-Gómez, Lipid imaging for visualizing cilastatin amelioration of cisplatin-induced nephrotoxicity. J. Lipid Res., 2018, 59, 1561.
  • S.A. Aboulmagd, D. Esteban-Fernández, E. Moreno-Gordaliza, B. Neumann, A.H. El-Khatib, A. Lazaro, A. Tejedor, M.M. Gómez-Gómez, M.W. Linscheid, Dual Internal Standards with Metals and Molecules for MALDI Imaging of Kidney Lipids, Anal. Chem., 2017, 89(23), 12727.
  • E. Moreno-Gordaliza, D. Esteban-Fernández, A. Lázaro, B. Humanes, S. Aboulmagd, A. Tejedor, M.W. Linscheid, M.M. Gómez-Gómez, MALDI-LTQ-Orbitrap mass spectrometry imaging for lipidomic analysis in kidney under cisplatin chemotherapy, Talanta, 2017, 164, 16.
  • S. Beck, J. Stengel, Mass spectrometric imaging of flavonoid glycosides and biflavonoids in Ginkgo biloba L., Phytochemistry, 2016, 130, 201-206.
  • S. Große, P. Wilke, H.G. Börner, Easy access toward functional patterns on cellulose paper by combining laser printing and material specific peptide adsorption, Angew. Chem. Int. Edit., 2016, 55, 11266-11270.
  • J. Mehlhorn, T. Lindtner, F. Richter, K. Glaß, H. Steinocher, S. Beck, P. Hegemann, J.T.M. Kennis, and T. Mathes, Light-induced rearrangement of the β5 strand in the BLUF photoreceptor SyPixD (Slr1694), J. Phys. Chem. Lett., 2015, 6(23), 4749-4753.
  • G. Schwarz, S. Ickert, N. Wegner, A. Nehring, S. Beck, R. Tiemann and M.W. Linscheid*, Protein quantification by elemental mass spectrometry: An experiment for graduate students, J. Chem. Educ., 2014, 91(12), 2167-2170.